ea0020p531 | Paediatric Endocrinology | ECE2009
Baiocchi Michela
, Donati Chiara
, Maselli Mara
, Mella Patrizia
, Prandi Elena
, Pilotta Alba
, Radetti Giorgio
, Buzi Fabio
GH has contra-insulin actions and exogenous GH can reversibly reduce insulin sensitivity in patients treated with GH. It has been recently reported that the exon 3 deleted (d3) isoform of the GH receptor (GHR) appears to be preventive for type 2 diabetes mellitus in adult subjects (GH&IGF Res 2007;17:392). Aim of this study was to investigate possible influences of the GHR-d3 polymorohism on glucose metabolism, lipid profile and BMI in children treated with GH for G...